Relationships Between Opioid Dosing, Pain Severity, and Disability in a Community-Based Chronic Pain Population: An Exploratory Retrospective Analysis

DiBenedetto DJ, Wawrzyniak KM, Finkelman M, Kulich RJ, Chen L, Schatman ME, Stone MT, Mao J. Relationships Between Opioid Dosing, Pain Severity, and Disability in a Community-Based Chronic Pain Population: An Exploratory Retrospective Analysis. Pain Med. 2019 Nov 1;20(11):2155-2165. doi: 10.1093/pm/pny240. PMID: 30657983.
https://pubmed.ncbi.nlm.nih.gov/30657983/

Objective: To determine the relationship between opioid dose change, pain severity, and function in patients with chronic pain.

Design: Retrospective cohort study.

Setting: Community interdisciplinary pain management practice.

Subjects: A total of 778 patients with chronic pain prescribed opioids for three or more consecutive months between April 1, 2013, and March 1, 2015.

Methods: Changes in opioid dose, pain severity rating, modified Roland Morris Disability Questionnaire score, and opioid risk data were extracted from medical records and analyzed for associations.

Results: Two hundred forty-three subjects (31.2%) had an overall dose decrease, 223 (28.7%) had a dose increase, and 312 (40.1%) had no significant change in dose (<20% change). There was a weak negative correlation between change in opioid dose and change in pain severity (r = -0.08, P = 0.04) but no association between change in disability scores and dose change (N = 526, P = 0.13). There was a weak positive correlation between change in pain severity rating and change in disability scores (r = 0.16, P < 0.001).

Conclusions: The results suggest that escalating opioid doses may not necessarily result in clinically significant improvement of pain or disability. Similarly, significant opioid dose reductions may not necessarily result in worsened pain or disability. This exploratory investigation raised questions of possible subgroups of patients who might demonstrate improvement of pain and disability with opioid dose adjustments, and further research should prospectively explore this potential, given the limitations inherent in retrospective analyses. Prescribers should still consider reduction of opioid doses as recommended by current guidelines, in an effort to mitigate the potential risks associated with high-dose treatment.

Keywords: Aberrancy; Chronic Pain; Dose; Function; Opioid; Taper.